Research update from Dr. Maya Koronyo-Hamaoui, 2012 CART Grant Recipient:
A paper published by Dr. Maya Koronyo-Hamaoui and colleagues from the department of Neurosurgery, Maxine-Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA is named the “Editor’s Choice” for August 2015 in the Oxford University journal Brain.
This large, multi-year study shows for the first time that that infiltrating monocyte-derived macrophages contribute to the clearance of amyloid-beta in the brain.
Koronyo et al. show that monthly injection of a subset of bone marrow monocytes into the peripheral blood of symptomatic Alzheimer’s disease mouse models, and/or weekly immunization with glatiramer acetate, substantially reduces cognitive decline. The improved cognition is associated with synaptic preservation.
Therapeutic effects of glatiramer acetate and grafted CD115+ monocytes in a mouse model of Alzheimer’s disease (http://brain.oxfordjournals.org/content/138/8/2399 ), Yosef Koronyo, Brenda C. Salumbides, Julia Sheyn, Lindsey Pelissier, Songlin Li, Vladimir Ljubimov, Michelle Moyseyev, David Daley, Dieu-Trang Fuchs, Michael Pham, Keith L. Black, Altan Rentsendorj, Maya Koronyo-Hamaoui. Brain (2015) 138 (8): 2399-2422 DOI: http://dx.doi.org/10.1093/brain/awv150 First published online: 6 June 2015 (24 pages).
This research was funded in part by a grant from The CART Fund. The CART Fund contributes to the prevention and cure of Alzheimer’s Disease through seed-money grants for Alzheimer’s research. One-hundred percent of every dollar donated to The CART Fund goes to Alzheimer’s research. The CART Fund is a 501(c)(3) organization. www.cartfund.org