Emory University’s Alzheimer’s Disease Research Center will receive a transformational donation to support advanced research into early detection of Alzheimer’s disease.
The Goizueta Foundation is committing $25 million toward research aimed at fundamentally changing the way Alzheimer’s disease is detected and treated.
Dr. Allan Levey, recipient of the first CART grant in 1999 is the Director of Emory’s Alzheimer’s Disease Research Center (ADRC).
Dr. Levey currently serves on the three-person Scientific Review Panel that reviews projects for the 2015 CART Fund grants.read more
Dr. Bruce Lamb and colleagues from Cleveland Clinic’s Lerner Research Institute demonstrate the true role of TREM2 in AD in study published in The Journal of Experimental Medicine.
Previously thought to protect against Alzheimer’s, Dr. Lamb has discovered that TREM2 actually promotes the disease.
Deleting the TREM2 receptor in mice decreased plaque formation, reduced brain inflammation, and improved the survival of neurons. This protection was associated with fewer infiltrating macrophages. Macrophages lacking TREM2 were apparently better at engulfing beta-amyloid aggregates, suggesting that they might assist in the brain clean-up effort.
Although additional studies are needed to clarify the exact mechanism of TREM2’s action in AD, these results suggest that toning down the receptor’s activity may help put a stop to neurodegeneration in AD patients.read more
Looking for Fast Facts on The CART Fund? The October 2014 CART Fast Facts sheet is now available! Download your copy now!read more
Looking for the latest CART news and information? The September 2014 CART Newsletter is now available! Download your copy now!read more