•The initial grant of $100.000.00 was made in April 1999 by D-7770 to Emory University and Dr. Allan Levey, the leader of its Alzheimer’s research team. Of the 8 research centers invited to apply for this initial grant, applications were received from Harvard University, the University of Pennsylvania, Johns Hopkins University, Duke University, Emory University, the Medical University of South Carolina, and the Mayo Clinic.
•After the first CART grant for $100,000 was made to Emory University, the second CART grant was awarded in May 2001. A $250,000 grant was made to CASE Western Reserve University’s Alzheimer’s Research Department, Karl Herrup, Ph.D. and Gary Landreth, Ph.D. covering a two-year grant.)
•The third grant was awarded in April 2002: Johns Hopkins School of Medicine, Philip Wong, Ph.D. and Donald Price, Ph.D. receives CART’s third grant in the amount of $250,000.
•In April 2003, CART’s fourth grant in the amount of $250,000 was awarded to the University of Pennsylvania School Of Medicine, John Trojanowski, M.D., and Ph.D.
•CART Treasurer Roger Ackerman announced that the Fund exceeded $1 million in receipts in July 2003.
•In May 2004 the University Of Connecticut Health Center, Robert Reenan, Ph.D., was announced as the recipient of CART’s fifth grant in the amount of $250,000.
•The sixth grant of the CART Fund was presented to Dr. Gary Small and his research team from University of California at Los Angles in May 2005. The grant was for $250,000.
•In May 2006, The University of Texas – Medical Branch, Claudio Soto, Ph.D., was awarded the seventh grant of the CART Fund in the amount of $250,000.
•May 2007 saw the Mayo Clinic in Jacksonville FL, Todd Golde, Ph.D., receive the eighth grant from CART for $250,000
•In May 2008, thanks to generous support from Rotarians and others, it was possible to award two grants (#9 and #10) for the first time. The Cleveland Clinic and Sanjay W. Pimplikar, Ph.D, received a $250,000 grant, and The University of Alabama-Birmingham Medical Center and J. David Sweatt, Ph.D. received a $200,000 grant.
•The practice of awarding two grants continued in May 2009, when the University of Kentucky’s Harry LeVine.III, Ph.D, was awarded CART’s eleventh grant for $250,000 and the Mayo Clinic, Jacksonville, Fl and Malcom Leissring, Ph.D were awarded the twelfth for $200,000.
In May of 2010 the Board awarded three grants for the first time: University of Kentucky: Paul Murphy M.D. $250,000; University of Wisconsin: Luigi Puglielli M.D., Ph.D. $100,000; Pennsylvania State University: Kurt Brunden Ph.D. $50,000; Dr. Brunden was our very first “Pilot Grant”. We were convinced by our Research Scientists that a pilot grant would spur a great research idea and inspire young researcher in a promising way. The Pilot Grant was for one year and $50,000.
May of 2011: the CART Board selected three promising researchers from the following institutions. Massachusetts General Hospital – Boston: Brad Hyman M.D., Ph.D. $50,000; Case Western – Reserve: Gary Landreth Ph.D.; Pennsylvania State University, $100,000: Kurt Brunden Ph.D., $250,000. Again the board elected to offer the second Pilot Grant recommended by our research panel of scientist in 2010.
May of 2012: the Research Scientist Panel recommended and the Board awarded research grants to our first lady Researcher. Cedars-Sinai Medical Center, Los Angeles: Maya Koronyo-Hamaoui Ph.D., $250,000; and the secondary award also went to a lady Researcher at the University of Washington, Seattle: Valerie Daggett Ph.D., $100,000. We are excited by the quality and dedication of all of our researchers; however, it was especially gratifying to see the ladies recognized for their unique cutting edge research that brings such promise to our cause.
May 2013, The Cart Board awarded grants to Children’s Hospital Boston, Beth Stevens, Ph.D. ($250,000) and to the Lerner Research Institute, Bruce Lamb, Ph.D. ($100,000)
Quotes from some of CART’s grant recipients:
Upon receiving CART’s fourth grant at the University of Pennsylvania, Dr. John Trojanowski commented: “Funding from sources like Rotarians allow us to jump-start scientific research on the many targets that we think are molecular pathways to curing Alzheimer’s. It is remarkable that just a few citizens can band together to recognize a need and with deliberation and foresight, deliver major awards on the level of a large foundation or government agency.”
Dr. Gary Landreth of Case Western Reserve University received a grant in 2001 to support work on a then-novel class of drugs. Dr. Landreth stated, “The CART funds were absolutely critical to our success, as they allowed us to pursue experiments investigating the mechanism of drug action for which we had no other means of support.” He further advised that this research has led to three phases of testing involving expenditures in excess of $200 million dollars. It’s another example of how CART “seed funds” may lead to major research grants from the National Institute of Health and other groups.
Drs. Allan Levey and Jim Lau of Emory University: Dr. Lau, commenting on the discovery of the SORL 1 gene and its connection to CART. “The connection is simple. Our work (funded by CART) led to the first association of the SORL 1 protein (also called LR 11) with AD. That sparked interest and led directly to the study of SOTL 1 and other related genes by a very large consortium of genetics researchers.”
Dr. Gary Small of UCLA: “our group remains deeply appreciative for the funding we received from your program several years ago. The CART Grants Program clearly helped us to move the field forward through its funding of our project, which led to improved understanding of our amyloid plaque and tau tangle PET technology in mild cognitive impairment.”
Dr. Sanjay Pimplicar of Cleveland Clinic: “We have shown that a part of amyloid precursor protein, called AICD, causes tau to aggregate and we all know that tau aggregation is bad. Thus my findings that AICD could be the real culprit in AD have gained more credibility. Thus, the CART funding is supporting novel and cutting edge research.”
Dr. David Sweatt of the University of Alabama at Birmingham: “CART funding will be critical for my laboratory to be able to aggressively pursue a new drug development opportunity that we have, that hopefully will lead to a new type of treatment for Alzheimer’s disease.”
Dr. Todd Golde, Mayo Clinic, Jacksonville: “Through funding provided by the CART award we will evaluate how several different types of compounds that modulate production of the amyloid beta protein work to modulate amyloid beta protein deposition in the brain of an Alzheimer’s disease mouse model.”
In a follow up two years after the CART grant was made, Dr. Golde commented: “… CART funding was vital in our getting an NIH grant renewed that has been awarded to both Eddie Koo and myself and is for $2.5 million dollars over 5 years.
Dr. Harry Levine, the University of Kentucky: “Thank you so much for allowing me to be part of the CART Fund annual meeting and to give those who worked so hard soliciting the funds that I will be using for research a taste of what we are trying to do. I was very much impressed with the dedication of the group and how much you have been able to accomplish, both in raising funds and awareness. I think that bringing in the grantees like this is a great way to build a personal bond between the organization and the researchers. It helps researchers remember the people who are working with us in this struggle to defeat an insidious disease. Sometimes research gets pretty lonely and it’s a reconnection like this that reminds me exactly why I work on Alzheimer’s disease… I will be in touch and hope that I will have exciting results to report soon.