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Nigel J. Cairns – Washington University School of Medicine, St. Louis ($250,000 Grant)

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Nigel J. Cairns – Washington University School of Medicine, St. Louis ($250,000 Grant)

  On May 6, 2014, at the annual meeting of The CART Fund, Nigel J. Cairns, PhD, FRCPath, Professor, Department of Neurology, Washington University School of Medicine, St. Louis, MO was awarded a CART Grant in the amount of $250,000. Research Project Although we have learned a great deal about the biology of Alzheimer’s in recent years there is still no effective treatment. Dr. Cairns and colleagues plan to use the CART award to investigate a promising new molecule to see if it can slow down or stop the damage caused to nerve cells by the disease. Firstly, he plans to investigate how this new molecule works in the test tube and, secondly, he will investigate its...

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Tsuneya Ikezu – Boston University School of Medicine ($100,000 Grant)

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Tsuneya Ikezu – Boston University School of Medicine ($100,000 Grant)

  On May 6, 2014, at the annual meeting of The CART Fund, Tsuneya Ikezu, MD, Ph.D., Professor Departments of Pharmacology & Experimental Therapeutics and Neurology at Boston University School of Medicine was awarded a CART grant in the amount of $100,000. Research Project My funded research is focused on how the disease hallmark protein called tau starts to build up in nerve cells in a stereotypical manner. We hypothesize that brain immune cells secrete tiny particles containing the tau protein, and then they spread this toxic protein into other nerve cells. We will identify the tau spreading mechanism and invent a small molecule therapeutic using newly created...

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Ben A. Bahr – University of North Carolina – Pembroke ($100,000 Grant)

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Ben A. Bahr – University of North Carolina – Pembroke ($100,000 Grant)

  On May 6, 2014, at the annual meeting of The CART Fund, Ben A. Bahr, Ph.D., the William C. Friday Distinguished Professor of Molecular Biology and Biochemistry of the University of North Carolina – Pembroke was awarded a CART grant in the amount of $100,000. Research Project Millions of baby boomers fear Alzheimer’s disease is an impending epidemic, with age-related imbalances between protein production and protein clearance increasing their risk for the disease as they age. To reduce the different proteins that accumulate in Alzheimer’s disease, the CART project in the Bahr Lab is studying a newly identified class of compounds that enhances the protein...

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Chuanhai Cao – University of South Florida ($50,000 Grant)

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Chuanhai Cao – University of South Florida ($50,000 Grant)

  On May 6, 2014, at the annual meeting of The CART Fund, Chuanhai Cao, Ph.D., Assistant Professor, College of Pharmacy, Department of Pharmaceutical Science, was awarded a CART grant in the amount of $50,000. Research Project There is a need to develop new and effective treatments to combat the devastating neurodegenerative disorder Alzheimer’s Disease (AD). Our research proposes to examine a safer vaccine / therapy method which uses immune cells called dendritic cells (DC) which induces effective immune responses against the beta amyloid, when used to stimulate the DCs. This method will be used in mouse model, which demonstrates some of the symptoms and disease...

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Dr. Allan Levey Receives NIH AD grant for $7.2M

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Dr. Allan Levey Receives NIH AD grant for $7.2M

  Dr. Allan Levey, MD, Ph.D., of Emory University, has received a grant from the National Institutes of Health (NIH) for $7.2M for Alzheimer’s disease research.  The purpose of this study is to discover proteins ‘beyond the usual suspects of beta-amyloid and tau’ that are altered by Alzheimer’s disease, in an effort to identify new targets for therapies. Dr. Levey received the first CART Grant awarded in 1999. Six university research centers will collaborate in this research.  Five of the participating research centers are CART Grant recipients: Emory University, UCLA, University of Washington, University of Pennsylvania and Johns Hopkins.  Rush...

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Early AD Diagnosis with Retinal Scans – Dr. Maya Koronya-Hamaoui, Cedars-Sinai

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Early AD Diagnosis with Retinal Scans – Dr. Maya Koronya-Hamaoui, Cedars-Sinai

  Exciting progress on an effort to diagnose Alzheimer’s Disease with retinal scans was announced at the Alzheimer’s Association International Conference in Denmark in July 2014. This safe, early, non-invasive diagnosis of Alzheimer’s using retinal scans is based on the research of 2012 CART grant recipient Dr. Maya Koronyo-Hamaoui of Cedars-Sinai Medical Center. NeuroVision Imaging has helped translate Dr. Koronyo-Hamaoui’s unique retinal amyloid imaging approach and technology (using curcumin labeling) into the clinical settings for early Alzheimer’s...

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